Made and checked in the U.S. Compounded by a licensed 503A pharmacy, then shipped cold, sealed and discreet to your door.
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GLP‑1s,
done right.
- Pharmaceutical-grade compounded GLP-1, prepared by a licensed U.S. 503A pharmacy
- Physician-guided care, reviewed by a US-licensed doctor before anything ships
- One clear price with no membership fee, and it doesn't rise as your dose does
Monthly pricing at every dose
Semaglutide
$99/mo*
Tirzepatide
$199/mo*
Takes about 2 minutes. You’re only charged if a physician approves.
Compounded medications are not FDA-approved and are not the same as the brand-name versions.
- No membership required
- Same price at every dose
- Only charged if a physician approves
- Physician-prescribed
- Shipped to your door
- No insurance required
- HSA/FSA cards accepted
- All 50 states
More than medication.
A complete system.
Most programs stop at the prescription. Protocol MD brings the medication, the physician review and the care around it together under one clear price.
Built around your life. Refills, dose changes and questions handled online — no waiting rooms, no insurance paperwork.
Decided by physicians. A US-licensed doctor reviews every order and prescribes only when it is appropriate.
Appetite is a hormone.
Not a character test.
Hunger, hormones and metabolism can all work against you. That is why compounded semaglutide and tirzepatide are prescribed by a US‑licensed physician and stepped up on clinical judgement, not a fixed calendar.
- Hunger is a signal.
- GLP‑1 acts on the messaging between gut and brain that governs appetite and fullness.
- Hormones shift.
- Age, sleep, stress and metabolic health change how the body stores weight over time.
- The body pushes back.
- Metabolism adapts when weight comes off, which is why every restart feels harder than the last.
Know exactly
what you’re taking.
Two compounded GLP‑1 medications, prepared by a licensed U.S. 503A pharmacy and reviewed by a US‑licensed physician before anything ships.
$99/mo*
Semaglutide
CompoundedOnce weekly
Physician-guided GLP‑1 program, built around you. One price at every dose.
Get started- Single-pathway GLP‑1 receptor agonist — the molecule studied in the STEP trials.
- Prepared by a licensed U.S. 503A pharmacy under USP <797>
- Reviewed by a US-licensed physician before anything ships
- Dose stepped up on a physician-set schedule, same price
Compounded in the U.S.A. FSA & HSA Eligible
$199/mo*
Tirzepatide
CompoundedOnce weekly
Physician-guided GLP‑1 program, built around you. One price at every dose.
Get started- Dual-pathway GLP‑1 + GIP receptor agonist — the molecule studied in the SURMOUNT trials.
- Prepared by a licensed U.S. 503A pharmacy under USP <797>
- Reviewed by a US-licensed physician before anything ships
- Dose stepped up on a physician-set schedule, same price
Compounded in the U.S.A. FSA & HSA Eligible
*Starting prices on the 12‑month plan; full pricing terms below. Whether either medication is appropriate for you is decided by a US‑licensed physician.
Support, built in.
Everything included in one clear price.
Physician review on every order
Message the care team from your patient portal
Care team
How are you feeling on this week’s dose?
Good — a little nausea day two, then fine.
Normal for this step. We’ll note it for the physician before your next refill.
Dose stepped up on a physician-set schedule
Priority medication delivery from a U.S. compounding pharmacy
Cancel anytime. No retention calls, no fee.
Auto-renew
Future renewals stopped. No call required, no cancellation fee.
Cancelled in one tap
One clear price. No membership fee on top.
Medication + physician review$99/mo*
Cold-chain shippingIncluded
Membership fee$0
Your price$99/mo*
The vial is small.
What’s inside matters.
Made with intention. Checked with discipline. Shipped cold.
Active peptide. The prescribed GLP‑1 your plan is built around.
Pharmaceutical-grade base. Compounded to USP standards by a licensed 503A pharmacy.
Once-weekly design. A long-acting molecule, so the routine is weekly, not daily.
Sterile preparation. Prepared under USP <797> sterile-compounding controls.
Physician-set dose. Stepped up on a clinician's schedule, never on guesswork.
Cold-chain packed. Temperature-controlled from the pharmacy to your door.
Takes about 2 minutes Made in the U.S.A. Shipped cold
Made in the U.S.A.
Checked before it ships.
Where it is prepared, and what is checked before a vial leaves the pharmacy.
Made in the U.S.A.
Prepared in a licensed U.S. 503A compounding pharmacy under controlled sterile conditions.
- USP <797>
- Sterile processing. Careful handling. Controlled release.
- 503A
- Patient-specific, prescription-only compounding.
Checked, not assumed
- Third-party tested
- Prescription only
- Physician-reviewed
- Lot-tracked
- Cold-shipped
- Discreet packaging
Built to a standard.
Checked against it.
- Third-party tested
- Lot-tracked
- Physician-reviewed
- Cold-shipped
- Prescription only
A once-weekly routine,
by design.
Even the box is considered: one small injection a week, every supply for it packed alongside the medication, and a care team a message away from the first dose.
- Once a week
- One small subcutaneous injection, not a daily pill or a daily shot.
- Everything in the box
- Supplies for each dose ship with the medication, cold-chain, to your door.
- Guided from the first dose
- Step-by-step instructions, and a care team you can message between refills.
Semaglutide & tirzepatide available now
Care that comes from real practice.
Most telehealth programs are built entirely online. Protocol Health is a working clinic, so what we ask and how we guide online is shaped by real patients and real visits.
Protocol Health · Scarsdale, New York
Protocols shaped in person. What the clinical team learns face-to-face in Scarsdale informs the questions and guidance we use online.
A physician-led practice. Protocol Health is family-owned and physician-led — hormone optimization, peptide therapy and medical weight loss under one roof.
The same standard, online. Protocol MD extends that standard nationally, with every order reviewed by a US-licensed physician.
Real people
behind every step.
Behind every plan is a clinical team — the questions, the guidance and the everyday support that make progress possible.
Richard Dentico, MD
Chief Medical Officer, Protocol MD
Erisa Auricchio, FNP-BC
Family Nurse Practitioner, Protocol MD
Kimberly Garvey, PA-C
Physician Assistant, Protocol MD
Start online.
Stay supported.
Four simple steps.
- 1
Tell us about you
A short online assessment about your health, goals and history.
About 2 minutes
- 2
A physician reviews it
A US-licensed doctor reviews your assessment and prescribes only if appropriate. You're only charged if approved.
Physician review
- 3
Delivered to your door
Prepared by a licensed 503A pharmacy and shipped cold, in plain packaging.
Cold-chain
- 4
Stay supported
Dose steps, check-ins and questions handled from your patient portal.
Ongoing
Start your personalized assessment
Takes about 2 minutes Only charged if a physician approves
Published trial averages, not a prediction
How much did people actually lose?
Set your height and weight and see the range the trials reported for people like you.
Typical response in the trial:
36 lbs
About 15% of body weight at about 68 weeks (roughly 16 months), STEP-1. About half of trial participants lost at least this much. The trial average was 14.9%.
Lower response
−12 lbs
5% · to 228 lbs
Typical response
−36 lbs
15% · to 204 lbs
Strong response
−48 lbs
20% · to 192 lbs
Takes about 2 minutes Only charged if a physician approves
Based on average results from clinical trials of the FDA-approved brand-name medications. This is a range of published outcomes, not a prediction of your results.
- Not everyone responds. In the semaglutide trial, roughly 1 in 7 participants lost less than 5% of their body weight. There is no way to know in advance which group you would fall into.
- These results come from trials of the FDA-approved brand-name products. Protocol MD's semaglutide and tirzepatide are compounded. Compounded medications are not FDA-approved, are not generic equivalents of, and are not the same product as, the brand-name medications studied in these trials.
- Trial participants also received structured lifestyle support — reduced-calorie eating and increased physical activity — alongside the medication.
- Weight loss in these trials was gradual across the full study period, with the steepest phase in the early months and a plateau toward the end. It is not a matter of weeks.
- Weight regain after stopping is common. In a follow-up of the semaglutide trial, participants regained about two-thirds of their lost weight in the year after treatment ended.
Change you
can measure.
What the published trials reported for each molecule.
−48 lbs
Tirzepatide: a 20% average body-weight change at about 72 weeks (roughly 17 months), SURMOUNT-1 — about 48 lbs at a 240 lb starting weight.
−15%
Semaglutide’s average at about 68 weeks (roughly 16 months), STEP-1 — about 36 lbs at the same starting weight.
72 wks
The length of the trial behind that average. Steepest early, flattening toward the end — not a matter of weeks.
Average results from clinical trials of the FDA-approved brand-name medications (SURMOUNT-1 and STEP-1), converted to pounds at a stated 240 lb starting weight for illustration. This is a published average, not a prediction of your result, and the two trials enrolled different populations and are not directly comparable. Compounded medications are not FDA-approved and are not the same product as the medications studied. Trial participants also received structured lifestyle support. Your dose steps up on a physician’s schedule.
Questions before
you start?
The things people usually want to know first.
Am I guaranteed a prescription?
No. A US-licensed physician reviews every assessment and prescribes only when it is appropriate — and can decline. Your card is only charged if a physician approves.
Is compounded medication FDA-approved?
No. Compounded GLP‑1s have not been reviewed or approved by the FDA, and they are not brand-name products. Ours are prepared by a licensed U.S. 503A compounding pharmacy under USP <797> sterile standards.
What does the monthly price include?
The medication, the physician review, the supplies for each dose and cold-chain shipping. There is no membership fee. The $99 and $199 figures are the 12-month plan billed upfront; 3- and 6-month plans are available at checkout.
Is this an introductory price that goes up?
No. Your price is set by your plan, not your dose, and it does not rise as you titrate. Plans auto-renew at the same price until cancelled.
What if I have side effects or need a dose change?
Message the care team from your patient portal. Dose changes are decided by a physician, and the boxed-warning conditions are screened before anything is prescribed.
How long does it take?
In the trials behind these medications the full result took roughly 68 to 72 weeks. Loss was gradual, steepest in the earlier months, and flattened toward the end. It is not a matter of weeks.
Can I pay with an HSA or FSA card?
Yes. Enter it at checkout like any other card. Physician-prescribed medication is generally an eligible expense, and every charge has an itemized receipt in your patient portal if your plan reimburses instead. Plans vary, so confirm with your plan administrator.
Can I cancel?
Yes. Cancelling stops future renewals — no retention calls, no cancellation fee. A term already paid is not refunded.
Your next step is simple.
Answer one question and the assessment picks up from there.
Where are you starting from?
I’ve never taken a GLP‑1I’m taking one now and looking to switchI’ve taken one before and want to restartI’m still deciding if it’s right for me
Takes about 2 minutes. You’re only charged if a physician approves.
Richard Dentico, MD
Chief Medical Officer, Protocol MD