Compounded GLP-1 Injections

GLP-1 (glucagon-like peptide-1) is an incretin hormone involved in appetite and blood-sugar signalling. A GLP-1 receptor agonist acts on those same receptors and is given as a once-weekly injection. Ours is prepared by a US-licensed 503A compounding pharmacy — compounded medications are not FDA-approved, and a physician decides whether treatment is appropriate for you.

Semaglutide is a single GLP-1 receptor agonist; tirzepatide acts on two receptors (GIP and GLP-1). Both are once-weekly injections with broadly similar, mostly gastrointestinal side effects. In clinical trials of the brand-name products, tirzepatide produced greater average weight loss, but which is appropriate for you is a physician's decision based on your health history. Compounded medications are not FDA-approved. Read our full comparison.

As a once-weekly subcutaneous injection, on the same day each week unless your physician says otherwise. Treatment follows a gradual dose-escalation schedule your physician sets to support tolerance.

Gastrointestinal effects are the most commonly reported — nausea, vomiting, diarrhea, and constipation. They're a major reason treatment starts low and escalates gradually. Report any side effects to your physician, and seek medical attention for severe or persistent symptoms such as intense abdominal pain.

GLP-1 receptor agonists are not appropriate for people with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), and they're not for use during pregnancy or while trying to become pregnant. We're also not able to prescribe online for someone with a history of pancreatitis — that needs a direct conversation with a physician rather than an online intake. Our intake screens for all of these before any charge.

No. Compounded medications are prepared by a licensed compounding pharmacy and are not FDA-approved — the FDA has not evaluated them for safety or effectiveness. They are not generic equivalents of, or substitutes for, any brand-name product. Your physician can discuss the difference and whether compounded treatment is appropriate for you.

Individually. A US-licensed physician sets your starting dose and any escalation based on your history and how you respond, then adjusts over time. We don't publish dosing charts, because GLP-1 therapy should be dosed under medical supervision.

Protocol MD is cash-pay and transparently priced, with no membership fee and no surprise charges. Plans are billed upfront for the term you choose: the 12-month plan is $1,620 charged today, which works out to $135 per month. Shorter terms are available at a higher monthly rate, down to $179 for a single month. Your card is charged at checkout and refunded in full if a physician reviews your intake and decides not to prescribe.

You're refunded in full. A US-licensed physician reviews every intake and makes the prescribing decision — never an algorithm — and you're not charged for a treatment you aren't prescribed.

Yes — you can cancel anytime. Talk with your physician before stopping so they can advise on the right approach for you, and be aware that weight regain after discontinuing GLP-1 treatment is commonly reported.

You complete a short online intake, and a US-licensed physician (MD or DO) reviews your history and goals to decide whether a compounded GLP-1 is appropriate — a physician makes the call, never an algorithm. Your card is charged at checkout, and if they decide it isn't right for you, you're refunded in full.

Compounded by a US-licensed 503A compounding pharmacy — state-board licensed, USP <797> compliant, and a PCCA member, with every batch third-party lab tested for purity, identity, and sterility.

No insurance is required — Protocol MD is cash-pay and transparently priced, with no surprise fees. We provide an itemized receipt you can submit for reimbursement.

Care is available in all 50 states, 100% online — no in-person visit required. Intake, physician review, and follow-up all happen remotely with your care team.

Once a physician approves, your medication ships the next business day from the pharmacy in plain, unbranded, discreet packaging, with everything you need to begin.

Start the online intake and tell us about your goals. A US-licensed physician reviews it and, if a compounded GLP-1 is a fit, approves your protocol. Your care team stays available by message the whole way through.

A US-licensed physician (MD or DO) credentialed in your state. They review your intake within 24 hours and make the prescribing call — not an AI, not a non-clinician operator.

FedEx overnight, refrigerated cold-chain. Orders placed before 2pm ET typically ship same-day after physician approval and arrive the next business day.