Health Guide | Protocol MD

The peptide library, written by clinicians.

48 long-form articles on peptide therapy — what each compound does at the cellular level, who it's for, what the FDA says about it, and where the gray-market vendors get the story wrong. Every guide is reviewed by a US-licensed physician and updated as evidence evolves.

Articles

Zepbound vs Wegovy: How the Two Weight-Loss Drugs Compare

Zepbound is tirzepatide, Wegovy is semaglutide. They are approved for different conditions, priced very differently, and one leads on average weight loss.

Dr. Richard Dentico, MD · 12 min read

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Weight Loss · 11 min read

Tirzepatide Side Effects: What to Expect and What to Watch For

Most tirzepatide side effects are gastrointestinal and settle with time. Here's the full picture — common effects, the serious ones, the eye signal, and what compounded formulations add.

A woman sitting by a tall window in a quiet room, looking out at overcast daylight

Weight Loss · 9 min read

Long-Term Side Effects of Tirzepatide: What We Know and What We Don't

Tirzepatide's longest trials ran under two years, so genuinely long-term data doesn't exist yet. Here's exactly what that window shows, what it can't, and what to monitor.

Facial volume, protein and strength training as the levers that matter

Weight Loss · 9 min read

Ozempic Face: What Causes It and How to Avoid It

"Ozempic face" is facial volume loss from rapid weight loss, not a direct drug effect. Here's the mechanism, why it travels with hair shedding and muscle loss, and how to limit it.

A protein shake and eggs, both high in sulfur-containing amino acids

Weight Loss · 10 min read

Sulfur Burps on GLP-1 Medications: Causes and How to Get Rid of Them

Sulfur burps on Ozempic, Wegovy, Zepbound, Mounjaro, or compounded GLP-1s come from food sitting longer and fermenting. Here's what causes them and what actually helps.

Diagram showing the three subcutaneous injection sites: abdomen, thigh, and upper arm

Weight Loss · 12 min read

Where to Inject Semaglutide: Sites, Rotation, and What Actually Matters

Semaglutide is injected under the skin of the abdomen, thigh, or upper arm. Site choice doesn't change how well it works — rotating between sites is the part that does.

A hand cradling a bowl of ginger and lemon tea

Weight Loss · 9 min read

Semaglutide Nausea: Why It Happens and How to Relieve It

Nausea is the most common semaglutide side effect. Here's the mechanism, the timing pattern most people miss, what actually helps, and the symptoms that mean you should be seen.

The peptide library, written by clinicians.

Zepbound vs Wegovy: How the Two Weight-Loss Drugs Compare

Tirzepatide Side Effects: What to Expect and What to Watch For

Long-Term Side Effects of Tirzepatide: What We Know and What We Don't

Ozempic Face: What Causes It and How to Avoid It

Sulfur Burps on GLP-1 Medications: Causes and How to Get Rid of Them

Where to Inject Semaglutide: Sites, Rotation, and What Actually Matters

Semaglutide Nausea: Why It Happens and How to Relieve It

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