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NAD+
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell. It's central to mitochondrial energy production, DNA repair, and the activity of longevity-associated enzymes like sirtuins and PARPs.
From $232 / 12 weeks — includes physician review, 503A-compounded medication, and overnight cold-chain shipping. No charge until your physician approves.
- Async physician review within 24 hours
- Ships ready to inject — no reconstitution
- No subscription · billed once per cycle
- 503A US-compounded · Third-party lab tested
Overview
What Is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell. It's central to mitochondrial energy production, DNA repair, and the activity of longevity-associated enzymes like sirtuins and PARPs.
NAD+ levels decline significantly with age — measurable drops occur even in middle age. Restoring NAD+ via injection or IV supports cellular energy production and longevity-pathway activity.
What It Does
What Patients Use NAD+ For.
Cellular Energy Production
Direct substrate for mitochondrial ATP production.
DNA Repair Support
PARP enzymes use NAD+ to repair DNA damage.
Sirtuin Activation
Longevity-associated sirtuin enzymes require NAD+.
Cognitive Clarity
Some patients report sharper mental focus. Individual response varies.
Recovery Support
Cellular energy supports physical recovery.
Anti-aging Foundation
Often a foundational layer of a longevity protocol.
Mechanism of Action
Mitochondrial NAD+ Replenishment for Cellular Energy.
NAD+ is required for mitochondrial electron transport — without it, ATP production stalls. It's also the substrate for sirtuins (longevity enzymes) and PARPs (DNA repair enzymes).
Age-related declines in NAD+ have been linked to mitochondrial dysfunction, accumulating DNA damage, and reduced sirtuin activity. Restoring NAD+ addresses all three.
Who It's For
Who NAD+ Is For.
Energy & Cognitive Complaints
Fatigue, brain fog, reduced mental clarity in middle age.
Longevity Protocols
Foundation layer for comprehensive anti-aging approaches.
Recovery Support
Athletes and high-output professionals managing chronic fatigue.
Post-illness Recovery
Long-tail recovery from viral infections or extended stress.
Research
The Evidence Base.
NAD+ biology is one of the most-researched topics in longevity science. The mechanism is exceptionally well-characterized.
Therapeutic NAD+ administration is supported by clinical research and broad clinical practice.
503A-pharmacy compounded under USP-797 standards.
Dosing
Educational Only — Your Physician Sets the Protocol.
NAD+ can be given as a subcutaneous injection or an IV infusion. Your physician determines your dose, route, and protocol.
Protocol: continuous. Your physician sets the schedule.
Every protocol is reviewed and prescribed by a US-licensed physician. The information here is educational and not a substitute for clinical judgment.
FAQ
Common questions about NAD+.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell, central to mitochondrial energy production, DNA repair, and longevity enzymes like sirtuins. Levels fall measurably with age, which is why many longevity protocols focus on restoring it.
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Ready to start?
Find out if NAD+ is right for you.
Take the 90-second protocol quiz. A US-licensed physician reviews your case within 24 hours. No charge until they approve your protocol.