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NAD+ Injections
Starting at
$184/mo
What is NAD+ and why does it matter?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme in every cell, central to mitochondrial energy production, DNA repair, and longevity enzymes like sirtuins. Levels fall measurably with age, which is why many longevity protocols focus on restoring it.
What are the benefits of NAD+ injections?
Patients commonly pursue NAD+ for cellular energy, mental clarity, and recovery support as part of a longevity protocol. Individual response varies, and we make no disease-treatment claims — your physician sets expectations based on your goals.
Oral NAD+ (NMN, NR, liposomal) vs. injections — what's the difference?
Oral NMN and NR are NAD+ precursors your body must convert; injectable NAD+ is delivered more directly, which many patients find produces faster, more noticeable effects. Oral precursors still have a role in maintenance. Your physician helps you choose.
How It Works
Physician-prescribed, in three simple steps.
Free assessment, 100% online
Answer a few questions about your health history, lifestyle, and goals through our secure online medical intake. It takes about five minutes.
Physician review & prescription
A US-licensed physician reviews your intake and prescribes NAD+ only if it's clinically appropriate for you. We place a hold on your card at checkout and charge it only if they prescribe.
Delivered to your door
If prescribed, your medication ships cold-chain and discreetly to your door, with continuous physician oversight and simple refills.
Overview
What Is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell. It's central to mitochondrial energy production, DNA repair, and the activity of longevity-associated enzymes like sirtuins and PARPs.
NAD+ levels decline significantly with age — measurable drops occur even in middle age. Restoring NAD+ via injection or IV supports cellular energy production and longevity-pathway activity.
Who It's For
Who NAD+ Is For.
Energy & Cognitive Complaints
Fatigue, brain fog, reduced mental clarity in middle age.
Longevity Protocols
A foundation layer for cellular NAD+ support.
Recovery Support
Athletes and high-output professionals managing chronic fatigue.
Post-illness Recovery
Long-tail recovery from viral infections or extended stress.
How NAD+ works
Fuels the cell. Supplies its repair crew.
NAD+ is a coenzyme every cell uses to turn nutrients into usable energy. It also supplies two enzyme families — sirtuins and PARPs — that are involved in DNA repair and the regulation of inflammation.
Carries energy through the cell
NAD+ shuttles electrons through the reactions that produce ATP, the molecule cells spend on essentially everything they do.
Supplies the repair enzymes
Sirtuins and PARPs consume NAD+ as their fuel. Both are involved in repairing damaged DNA and in regulating the inflammatory response.
Declines with age
NAD+ levels fall as people get older. Subcutaneous injection delivers it without first passing through digestion, which is why it is given this way rather than swallowed.
Why NAD+
NAD+ falls as you get older.
It is the coenzyme your cells use to make energy.
Measured directly in human tissue
Researchers measured NAD+ in human tissue samples across a wide age range and found levels fall substantially as people get older, alongside rising markers of oxidative stress.
Source: Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ. PLoS ONE. 2012;7(7):e42357.
The same pattern in the living brain
Using a scanning technique that reads NAD levels in people rather than samples, this study found NAD in the brain declines with age in healthy adults — so the fall is not an artefact of how tissue is collected.
Source: Zhu XH, Lu M, Lee BY, Ugurbil K, Chen W. Proc Natl Acad Sci USA. 2015;112(9):2876-81.
What NAD+ actually does
NAD+ carries electrons through the reactions that turn food into usable energy, and it is the fuel for two enzyme families involved in DNA repair and in regulating inflammation. This review sets out that role and how it changes with age.
Source: Covarrubias AJ, Perrone R, Grozio A, Verdin E. Nat Rev Mol Cell Biol. 2021;22(2):119-41.
Charts are illustrative representations of published research and of the known properties of a medication class or active ingredient. They may simplify or normalise study data for clarity, describe general biology rather than any individual's result, and are not a prediction or guarantee of an outcome. A reference to a study or mechanism does not establish that any specific medication, formulation or treatment plan produces the same result. Compounded medications are not FDA-approved and are not evaluated by the FDA for safety, quality or effectiveness.
FAQ
Common questions about NAD+.
What is NAD+ and why does it matter?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme in every cell, central to mitochondrial energy production, DNA repair, and longevity enzymes like sirtuins. Levels fall measurably with age, which is why many longevity protocols focus on restoring it.
What are the benefits of NAD+ injections?
Patients commonly pursue NAD+ for cellular energy, mental clarity, and recovery support as part of a longevity protocol. Individual response varies, and we make no disease-treatment claims — your physician sets expectations based on your goals.
Oral NAD+ (NMN, NR, liposomal) vs. injections — what's the difference?
Oral NMN and NR are NAD+ precursors your body must convert; injectable NAD+ is delivered more directly, which many patients find produces faster, more noticeable effects. Oral precursors still have a role in maintenance. Your physician helps you choose.
IV vs. injection — which NAD+ route is right for me?
IV infusions deliver larger doses less frequently; subcutaneous injections allow smaller, more regular at-home dosing. Your physician recommends the route based on your goals and tolerance.
How is NAD+ dosing determined?
Dosing is individualized — a US-licensed physician sets your route (subcutaneous or IV), amount, and frequency based on your goals and how you respond, then adjusts over time. We don't publish dosing charts because NAD+ should be dosed under medical supervision, not from a template.
How is NAD+ prescribed through Protocol MD?
You complete a short online intake, and a US-licensed physician (MD or DO) reviews your history and goals to decide whether NAD+ is appropriate — a physician makes the call, never an algorithm. We place a hold on your card at checkout, and if they decide it isn't right for you, the hold is released and you're never charged.
Do I need insurance?
No insurance is required — Protocol MD is cash-pay and transparently priced, with no surprise fees. We provide an itemized receipt you can submit for reimbursement.
Ready to start?
Buy NAD+ Injections online, physician-prescribed.
Complete your medical intake. A US-licensed physician reviews it and prescribes only if appropriate. We place a hold at checkout and charge it only if a physician prescribes.