Research & Guides · Metabolic & Hormone Health

Metabolic & Hormone Health, written by clinicians.

7 physician-reviewed articles on metabolic & hormone health — what each compound does at the cellular level, who it's for, and what the evidence does and doesn't establish.

Articles

7

Pages

1

Avg Read

10 Min

Updated

2026

Comparing sermorelin and tesamorelin, two GHRH analogs

Featured · Metabolic & Hormone Health

Sermorelin vs. Tesamorelin: How the Two GHRH Analogs Actually Differ

Sermorelin and tesamorelin are both GHRH analogs, but tesamorelin is FDA-approved for one narrow condition while sermorelin is compounded for growth-hormone-axis support. An honest, physician-reviewed comparison.

Dr. Richard Dentico, MD · 7 min read

Read article
A gloved clinician's hand holding a prepared syringe in a clean clinical setting, representing physician-prescribed sermorelin dosing.

Metabolic & Hormone Health · 8 min read

Sermorelin Dosage: What Actually Determines Your Protocol

Sermorelin is typically started around 200–300 mcg by subcutaneous injection before bed, but there's no universal dose — a physician sets yours by age, weight, goals, and response. Here's what drives it.

Abstract rendering of peptide molecules suspended in golden serum spheres — sermorelin's mechanism and side-effect profile.

Metabolic & Hormone Health · 10 min read

Sermorelin Side Effects: What to Actually Expect

Sermorelin side effects, explained honestly by a physician — the common mild ones, the rare serious ones, how long they last, and when to call your doctor.

Man sleeping peacefully in morning sunlight — pulsatile growth hormone release during deep sleep is the mechanism sermorelin is designed to restore, unlike exogenous HGH.

Metabolic & Hormone Health · 12 min read

Sermorelin vs HGH: The Real Difference, Explained

Sermorelin and HGH both raise growth hormone — but in opposite ways. One signals your own pituitary to release GH in its natural pulsatile rhythm; the other floods the hormone in directly and bypasses your feedback loop. Here's the difference that actually matters.

What Lowers Testosterone? The Evidence-Based List (and the Myths That Don't Hold Up)

Metabolic & Hormone Health · 12 min read

What Lowers Testosterone? The Evidence-Based List (and the Myths That Don't Hold Up)

Alcohol, poor sleep, obesity, chronic stress, and certain medications genuinely lower testosterone. Masturbation and vasectomies don't. A physician's evidence-vs-myths breakdown.

Does Sermorelin Increase Testosterone? A Physician's Honest Answer

Metabolic & Hormone Health · 9 min read

Does Sermorelin Increase Testosterone? A Physician's Honest Answer

Sermorelin is a GHRH analog — it works on your GH axis, not your testosterone. Here's what the science actually shows, where the confusion comes from, and when you need a different conversation.

Sermorelin: The GHRH Analog With a Stranger History Than You Think

Metabolic & Hormone Health · 10 min read

Sermorelin: The GHRH Analog With a Stranger History Than You Think

Sermorelin was FDA-approved for 20 years, then quietly pulled — not for safety. Learn how this GHRH analog works, what the research shows, and when physician oversight matters.

503A US PharmacyPhysician-PrescribedUSP-Compliant Compounding

Built around you. Real medicine, designed by your physician.