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Available in all 50 statesMOTS-C Injections
A mitochondrial peptide, taken in cycles.
Starting at
$58/wk
Included in every plan
- Your physician, anytimeMessage them 24/7 from your portal
- A care team that answers fastReplies usually within 2 hours
- Your patient portalPlan, doses, orders and tracking
- Your bloodwork dashboardYour results, charted and explained
- AI Coach (Beta)Instant answers, 24/7
- Free shipping
- No insurance required
- Cancel renewal online
- A US-licensed physician reviews your intake and decides if it’s right for you
- Async physician review, usually within 2 hours
- Ships cold in discreet packaging
- No subscription · one payment for one cycle
MOTS-C injections are a physician-prescribed, 503A-compounded peptide that Protocol MD offers online in all 50 states. MOTS-C is a short peptide made by mitochondria, the parts of a cell that make energy. A US-licensed physician reviews your answers and decides if MOTS-C is right for you. Compounded medications are not FDA-approved, and MOTS-C is not FDA-approved for any use.
MOTS-C is a peptide. A peptide is a short chain of amino acids. MOTS-C has 16 of them. It is unusual because it is coded by DNA inside the mitochondria, the parts of a cell that make energy.
What is MOTS-C?
MOTS-C is a peptide made by mitochondria, the parts of a cell that make energy. It has 16 amino acids. Most of what is known about it comes from mouse and cell studies. Compounded medications are not FDA-approved, and MOTS-C is not FDA-approved for any use.
Who can't take MOTS-C?
You can't start MOTS-C if you are pregnant. The online visit asks this first, before you pay. A physician then reviews the rest of your health history after checkout and decides if MOTS-C is right for you.
How does a MOTS-C cycle work?
Each cycle is 6 weeks of MOTS-C, then a 4-week rest. You buy one cycle at a time. You pay once at checkout, and there is no subscription. It ships cold.
How It Works
Physician-prescribed, in three simple steps.
Free assessment, 100% online
Answer a few questions about your health history, lifestyle, and goals through our secure online medical intake. It takes about five minutes.
Physician review & prescription
A US-licensed physician reviews your intake and prescribes MOTS-C only if it's clinically appropriate for you. We place a hold on your card at checkout and charge it only if they prescribe.
Delivered to your door
If prescribed, your medication ships cold-chain and discreetly to your door, with continuous physician oversight and simple refills.
Overview
What Is MOTS-C?
MOTS-C is a peptide. A peptide is a short chain of amino acids. MOTS-C has 16 of them. It is unusual because it is coded by DNA inside the mitochondria, the parts of a cell that make energy.
Most of what is known about MOTS-C comes from studies in mice and in cells. Human research is early. Compounded medications are not FDA-approved, and MOTS-C is not FDA-approved for any use.
Protocol MD's MOTS-C is made for you by a US-licensed 503A compounding pharmacy. It is a shot you give yourself under the skin. It ships cold, so put it in the fridge when it arrives.
Who It's For
Who Asks About MOTS-C.
Adults Who Want a Physician's View
People who want a licensed physician, not a website, to decide if MOTS-C fits them.
People Focused on Metabolic Health
Patients often ask about it alongside food, sleep and exercise. It is not a replacement for any of them.
People Who Want a Real Pharmacy
Patients who want a 503A pharmacy and a prescription, not a 'research-only' vial from an online seller.
Not for Everyone
You can't start MOTS-C if you are pregnant. The online visit asks this first, before any charge.
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FAQ
Common questions about MOTS-C.
What is MOTS-C?
MOTS-C is a peptide made by mitochondria, the parts of a cell that make energy. It has 16 amino acids. Most of what is known about it comes from mouse and cell studies. Compounded medications are not FDA-approved, and MOTS-C is not FDA-approved for any use.
Who can't take MOTS-C?
You can't start MOTS-C if you are pregnant. The online visit asks this first, before you pay. A physician then reviews the rest of your health history after checkout and decides if MOTS-C is right for you.
How does a MOTS-C cycle work?
Each cycle is 6 weeks of MOTS-C, then a 4-week rest. You buy one cycle at a time. You pay once at checkout, and there is no subscription. It ships cold.
How much does MOTS-C cost?
Protocol MD is cash-pay, with no membership fee. One cycle is $349. We place a hold at checkout and only charge it if a physician approves. If not, the hold is released.
Is MOTS-C FDA-approved?
No. MOTS-C is not FDA-approved for any use. Protocol MD's MOTS-C is compounded for you by a US-licensed 503A pharmacy, and compounded medications are not FDA-approved. A physician decides if it is right for you.
How is MOTS-C prescribed through Protocol MD?
You complete a short online intake, and a US-licensed physician (MD or DO) reviews your history and goals to decide whether MOTS-C is appropriate — a physician makes the call, never an algorithm. We place a hold on your card at checkout, and if they decide it isn't right for you, the hold is released and you're never charged.
Do I need insurance?
No insurance is required — Protocol MD is cash-pay and transparently priced, with no surprise fees. HSA and FSA debit cards are accepted at checkout, and every charge has an itemized receipt in your patient portal for reimbursement. Physician-prescribed medication is generally an eligible expense, but plans vary, so check with your plan administrator.
In depth
What the Research on MOTS-C Shows So Far
The research on MOTS-C is early. Most of it is in mice and in cells, not in people. No large human trial has tested it as a treatment. Protocol MD sells MOTS-C, so read this section knowing we have a reason to want you to buy it.
- The first mouse studies — A 2015 study in Cell Metabolism, Lee and colleagues, first described MOTS-C. The work was in mice and cells. It looked at how MOTS-C acts on the way the body handles sugar.
- Exercise and aging in mice — A 2021 study in Nature Communications, Reynolds and colleagues, found that MOTS-C levels in people rose during exercise. It then tested MOTS-C in older mice. Mouse results do not tell you what will happen in a person.
- What is not known — No large, controlled human trial has tested MOTS-C as a treatment. Its long-term safety in people has not been studied. Compounded medications are not FDA-approved, and MOTS-C is not FDA-approved for any use.
So what can be said? MOTS-C is an interesting peptide in early research, with little human data. That is why a US-licensed physician reviews every Protocol MD request for MOTS-C, and why no outcome is promised. Start the online visit to see if a physician thinks it fits you.
Medically reviewed by Dr. Richard Dentico, MD. This page is educational and is not medical advice. It does not establish a patient relationship, and it is not a substitute for a consultation with your own clinician. Eligibility, dosing and treatment are decided by a US-licensed physician who reviews your intake and medical history.
Ready to start?
Buy MOTS-C Injections online, physician-prescribed.
Complete your medical intake. A US-licensed physician reviews it and prescribes only if appropriate. We place a hold at checkout and charge it only if a physician prescribes.
